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Title: Spectroscopic characterization and crystal structures of two cathinone derivatives : 1-(4-chlorophenyl)-2-(1-pyrrolidinyl)-pentan-1-one (4-chloro-α-PVP) sulfate and 1-(4-methylphenyl)-2-(dimethylamino)-propan-1-one (4-MDMC) hydrochloride salts, seized on illicit drug market
Authors: Kuś, Piotr
Kusz, Joachim
Książek, Maria
Pieprzyca, Ewelina
Rojkiewicz, Marcin
Keywords: 4-Chloro-α-PVP; 4-MDMC; infrared spectroscopy; NMR spectroscopy; Raman spectroscopy; X-ray crystallography
Issue Date: 2018
Citation: Forensic Toxicol, Vol. 36, Issue 1 (2018), s. 178-184
Abstract: Purpose: Two compounds newly found in the seizures by drug enforcement agencies were identified and characterized by various instrumental analytical methods. Methods: The obtained powder samples were analyzed by gas chromatography–mass spectrometry (GC–MS), liquid chromatography–mass spectrometryn (LC–MSn), nuclear magnetic resonance (NMR) spectroscopy, infrared and Raman spectroscopy and X-ray crystallography. Results: The two compounds were tentatively identified as 4-chloro-α-PVP and 4-MDMC by GC–MS, and LC–MS/MS. The confirmation of the results was made by NMR spectroscopy. The X-ray crystallography gave information that 4-chloro-α-PVP and 4-MDMC were in salted forms with sulfate and hydrochloride, respectively; in addition, both compounds existed as racemic mixtures. Conclusions: We could identify 4-chloro-α-PVP and 4-MDMC in the seizure powder samples by various analytical methods. X-ray crystallography was especially useful for identifying the salted forms and enantiomeric forms.
DOI: 10.1007/s11419-017-0381-x
ISSN: 1860-8965
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