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Title: The newest cathinone derivatives as designer drugs : an analytical and toxicological review
Authors: Majchrzak, Milena
Celiński, Rafał
Kuś, Piotr
Kowalska, Teresa
Sajewicz, Przemysław
Keywords: new synthetic cathinones; designer drugs; NPS; LC–MS; GC–MS; NMR
Issue Date: 2018
Citation: Forensic Toxicology, Vol. 36, iss. 1 (2018), s. 33-50
Abstract: Purpose: Currently, among new psychoactive substances, cathinone derivatives constitute the biggest group, which are mainly classified into N-alkylated, 3,4-methylenedioxy-N-alkylated, N-pyrrolidinyl, and 3,4-methylenedioxy-N-pyrrolidinyl derivatives. These derivatives are actively being subjected to minor modifications at the alkyl chains or the aromatic ring to create new synthetic cathinones with the goal of circumventing laws. In this review, the new synthetic cathinones that have appeared on the illegal drug market during the period 2014–2017 are highlighted, and their characterization by gas chromatography–mass spectrometry and liquid chromatography–tandem mass spectrometry is presented. Methods: Various key words were used to conduct an extensive literature search across a number of databases, specifically for synthetic cathinones that emerged between 2014 and 2017. Results: More than 30 new cathinone derivatives were discovered. The preexisting parental compounds for the new derivatives are also referenced, and their mass spectral data are compiled in a table to facilitate their identification by forensic toxicologists. Conclusions: To our knowledge, this is the most current review presenting new synthetic cathinones. Political authorities should take measures to implement and enforce generic scheduling (comprehensive system) laws to control the diversely modified synthetic cathinones. Supplementing the existing databases with new findings can greatly facilitate the efforts of forensic toxicologists.
DOI: 10.1007/s11419-017-0385-6
ISSN: 1860-8965
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