DC pole | Wartość | Język |
dc.contributor.author | Białek, Agnieszka | - |
dc.contributor.author | Stawarska, Agnieszka | - |
dc.contributor.author | Tokarz, Andrzej | - |
dc.contributor.author | Czuba, Katarzyna | - |
dc.contributor.author | Konarska, Anna | - |
dc.contributor.author | Mazurkiewicz, Magdalena | - |
dc.contributor.author | Stanimirova, Ivana | - |
dc.date.accessioned | 2019-04-23T07:40:09Z | - |
dc.date.available | 2019-04-23T07:40:09Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Acta Poloniae Pharmaceutica - Drug Research, Vol. 71, No. 5 (2014), s. 747-761 | pl_PL |
dc.identifier.issn | 0001-6837 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/8921 | - |
dc.description.abstract | The aim of this study was to assess the influence of diet supplementation of pregnant and breastfeeding
female Sprague-Dawley rats with conjugated linoleic acids (CLA) on the Δ6- and Δ5-desaturase activity
in hepatic microsomes as well as on fatty acids profile and lipids peroxidation in liver and hepatic microsomes
of the progeny with chemically induced mammary tumors. Rats were divided into two groups with different
diet supplementation (vegetable oil (which did not contain CLA) or CLA). Their female offspring was
divided within these groups into two subgroups: (1) ñ fed the same diet as mothers (K1 ñ oil, O1 ñ CLA), and
(2) ñ fed the standard fodder (K2, O2). At 50th day of life, the progeny obtained carcinogenic agent (7,12-
dimethylbenz[a]anthracene). Higher supply of CLA in diet of mothers resulted in lower susceptibility to chemically
induced mammary tumors in their offspring (p = 0.0322). It also influenced the fatty acids profile in livers
and in hepatic microsomes, especially polyunsaturated n3 and n6 fatty acids. CLA inhibited the activity of
the desaturases, which confirmed that CLA can reduce the level of arachidonic acid directly, reducing linoleic
acid content in membranes, or indirectly, through the regulation of its metabolism. We were unable to confirm
or deny the antioxidative properties of CLA. Our results indicate that the higher supply of CLA in mothersí diet
during pregnancy and breastfeeding causes their incorporation into tissues of children, changes the efficiency
of fatty acids metabolism and exerts health-promoting effect in their adult life reducing the breast cancer risk. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/pl/ | * |
dc.subject | conjugated linoleic acids | pl_PL |
dc.subject | Δ5-desaturase | pl_PL |
dc.subject | Δ6-desaturase | pl_PL |
dc.subject | breast cancer | pl_PL |
dc.subject | rats | pl_PL |
dc.title | Enrichment of maternal diet with conjugated linoleic acids influences desaturases activity and fatty acids profile in livers and hepatic microsomes of the offspring with 7,12-dimethylbenz[a] antracene- induces mammary tumors | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
|