DC pole | Wartość | Język |
dc.contributor.author | Knapik-Kowalczuk, Justyna | - |
dc.contributor.author | Chmiel, Krzysztof | - |
dc.contributor.author | Jurkiewicz, Karolina | - |
dc.contributor.author | Correia, Natalia T. | - |
dc.contributor.author | Sawicki, Wiesław | - |
dc.contributor.author | Paluch, Marian | - |
dc.date.accessioned | 2019-04-25T11:40:34Z | - |
dc.date.available | 2019-04-25T11:40:34Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Pharmaceuticals, Vol. 12, iss. 1 (2019), Art. No. 40 | pl_PL |
dc.identifier.issn | 1424-8247 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/8971 | - |
dc.description.abstract | The purpose of this paper is to examine the physical stability as well as viscoelastic
properties of the binary amorphous ezetimibe–simvastatin system. According to our knowledge,
this is the first time that such an amorphous composition is prepared and investigated. The tendency
toward re-crystallization of the amorphous ezetimibe–simvastatin system, at both standard storage
and elevated temperature conditions, have been studied by means of X-ray diffraction (XRD).
Our investigations have revealed that simvastatin remarkably improves the physical stability of
ezetimibe, despite the fact that it works as a plasticizer. Pure amorphous ezetimibe, when stored
at room temperature, begins to re-crystallize after 14 days after amorphization. On the other
hand, the ezetimibe-simvastatin binary mixture (at the same storage conditions) is physically
stable for at least 1 year. However, the devitrification of the binary amorphous composition was
observed at elevated temperature conditions (T = 373 K). Therefore, we used a third compound to
hinder the re-crystallization. Finally, both the physical stability as well as viscoelastic properties
of the ternary systems containing different concentrations of the latter component have been
thoroughly investigated. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | ezetimibe | pl_PL |
dc.subject | simvastatin | pl_PL |
dc.subject | co-amorphous | pl_PL |
dc.subject | melt viscosity | pl_PL |
dc.subject | solubility enhancement | pl_PL |
dc.title | Physical Stability and Viscoelastic Properties of Co-Amorphous Ezetimibe/Simvastatin System | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.3390/ph12010040 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
|