DC pole | Wartość | Język |
dc.contributor.author | Spaczyńska, Ewelina | - |
dc.contributor.author | Mrozek-Wilczkiewicz, Anna | - |
dc.contributor.author | Malarz, Katarzyna | - |
dc.contributor.author | Kos, Jiri | - |
dc.contributor.author | Gonec, Tomas | - |
dc.contributor.author | Oravec, Michal | - |
dc.contributor.author | Gawecki, Robert | - |
dc.contributor.author | Bąk, Andrzej | - |
dc.contributor.author | Musioł, Robert | - |
dc.contributor.author | Dohanosova, Jana | - |
dc.contributor.author | Kapustikova, Iva | - |
dc.contributor.author | Liptaj, Tibor | - |
dc.contributor.author | Jampilek, Josef | - |
dc.date.accessioned | 2019-05-09T08:08:19Z | - |
dc.date.available | 2019-05-09T08:08:19Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Scientific Reports, Vol. 9 (2019), Art. No. 6387 | pl_PL |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/9061 | - |
dc.description.abstract | A series of 116 small-molecule 1-hydroxynaphthalene-2-carboxanilides was designed based on the
fragment-based approach and was synthesized according to the microwave-assisted protocol. The
biological activity of all of the compounds was tested on human colon carcinoma cell lines including
a deleted TP53 tumor suppressor gene. The mechanism of activity was studied according to the p53
status in the cell. Several compounds revealed a good to excellent activity that was similar to or better
than the standard anticancer drugs. Some of these appeared to be more active against the p53 null cells
than their wild-type counterparts. Intercalating the properties of these compounds could be responsible
for their mechanism of action. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | 1-hydroxynaphthalene-2-carboxanilides | pl_PL |
dc.subject | Design and synthesis | pl_PL |
dc.subject | anticancer | pl_PL |
dc.title | Design and synthesis of anticancer 1-hydroxynaphthalene-2-carboxanilides with a p53 independent mechanism of action | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.1038/s41598-019-42595-y | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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