Skip navigation

Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorJaworska, Maria-
dc.contributor.authorLodowski, Piotr-
dc.contributor.authorMucha, A.-
dc.contributor.authorSzczepanik, W.-
dc.contributor.authorValensin, G.-
dc.contributor.authorCappannelli, M.-
dc.contributor.authorJeżowska-Bojczuk, M.-
dc.identifier.citationBioinorganic Chemistry and Applications, Vol. 2007, (2007), art. no. 53521pl_PL
dc.description.abstractInteractions between sinefungin and copper(II) ions were investigated. Stoichiometry and stability constants of themetal-free system and two mononuclear complexes present in solution were determined on the basis of potentiometricdata analysis. The results were compared to the Cu(II)-ornithine system due to structural similarities between bothmolecules. Combined spectroscopic and theoretical studies allowed for determination of coordination pattern forthe Cu(II)-sinefungin complexes. At acidic pH, copper is bound in "glycine-like" coordination mode, identical with thatof ornithine. This involves α-amino group and the carboxyl oxygen. At higher pH, a "bis-complex" is formed by twosinefungin molecules. The second ligand binds in equatorial position displacing two water molecules, what resultsin the stable 2N,2O coordination. Both axial positions are supposed to be occupied by N1 nitrogen donors of adeninemoiety, what is confirmed by DFT calculations. They interact indirectly with copper(II) through water molecules as theresult of dominant syn conformation of purine.pl_PL
dc.rightsUznanie autorstwa 3.0 Polska*
dc.subjectmetal complexespl_PL
dc.subjectethidium bromidepl_PL
dc.titleCharacterization of copper(II) interactions with sinefungin, a nucleoside antibiotic: Combined potentiometric, spectroscopic and DFT studiespl_PL
Appears in Collections:Artykuły (WNŚiT)

Files in This Item:
File Description SizeFormat 
Jaworska_Characterization_of_copper_II_interactions.pdf3,89 MBAdobe PDFView/Open
Show simple item record

Uznanie Autorstwa 3.0 Polska Creative Commons License Creative Commons