DC pole | Wartość | Język |
dc.contributor.author | Szade, Agata | - |
dc.contributor.author | Szade, Krzysztof | - |
dc.contributor.author | Nowak, Witold N. | - |
dc.contributor.author | Bukowska-Strakova, Karolina | - |
dc.contributor.author | Muchova, Lucie | - |
dc.contributor.author | Gońka, Monika | - |
dc.contributor.author | Żukowska, Monika | - |
dc.contributor.author | Cieśla, Maciej | - |
dc.contributor.author | Kachamakova-Trojanowska, Neli | - |
dc.contributor.author | Rams-Baron, Marzena | - |
dc.contributor.author | Ratuszna, Alicja | - |
dc.contributor.author | Dulak, Józef | - |
dc.contributor.author | Józkowicz, Alicja | - |
dc.date.accessioned | 2020-01-23T08:54:45Z | - |
dc.date.available | 2020-01-23T08:54:45Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | EMBO Molecular Medicine, 2019, iss. 12, art. no. e09571, s. 1-17 | pl_PL |
dc.identifier.issn | 1757-4676 | - |
dc.identifier.issn | 1757-4684 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/12170 | - |
dc.description.abstract | Granulocyte colony-stimulating factor (G-CSF) is used in clinical
practice to mobilize cells from the bone marrow to the blood;
however, it is not always effective. We show that cobalt protoporphyrin
IX (CoPP) increases plasma concentrations of G-CSF, IL-6,
and MCP-1 in mice, triggering the mobilization of granulocytes
and hematopoietic stem and progenitor cells (HSPC). Compared
with recombinant G-CSF, CoPP mobilizes higher number of HSPC
and mature granulocytes. In contrast to G-CSF, CoPP does not
increase the number of circulating T cells. Transplantation of
CoPP-mobilized peripheral blood mononuclear cells (PBMC) results
in higher chimerism and faster hematopoietic reconstitution than
transplantation of PBMC mobilized by G-CSF. Although CoPP is
used to activate Nrf2/HO-1 axis, the observed effects are Nrf2/HO-
1 independent. Concluding, CoPP increases expression of mobilization-
related cytokines and has superior mobilizing efficiency
compared with recombinant G-CSF. This observation could lead to
the development of new strategies for the treatment of neutropenia
and HSPC transplantation. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | CoPP | pl_PL |
dc.subject | Granulocyte colony-stimulating factor | pl_PL |
dc.subject | Hematopoietic stem and progenitor cells | pl_PL |
dc.subject | HO-1 | pl_PL |
dc.subject | Mobilization | pl_PL |
dc.title | Cobalt protoporphyrin IX increases endogenous G-CSF and mobilizes HSC and granulocytes to the blood | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.15252/emmm.201809571 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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