http://hdl.handle.net/20.500.12128/12170
Tytuł: | Cobalt protoporphyrin IX increases endogenous G-CSF and mobilizes HSC and granulocytes to the blood |
Autor: | Szade, Agata Szade, Krzysztof Nowak, Witold N. Bukowska-Strakova, Karolina Muchova, Lucie Gońka, Monika Żukowska, Monika Cieśla, Maciej Kachamakova-Trojanowska, Neli Rams-Baron, Marzena Ratuszna, Alicja Dulak, Józef Józkowicz, Alicja |
Słowa kluczowe: | CoPP; Granulocyte colony-stimulating factor; Hematopoietic stem and progenitor cells; HO-1; Mobilization |
Data wydania: | 2019 |
Źródło: | EMBO Molecular Medicine, 2019, iss. 12, art. no. e09571, s. 1-17 |
Abstrakt: | Granulocyte colony-stimulating factor (G-CSF) is used in clinical practice to mobilize cells from the bone marrow to the blood; however, it is not always effective. We show that cobalt protoporphyrin IX (CoPP) increases plasma concentrations of G-CSF, IL-6, and MCP-1 in mice, triggering the mobilization of granulocytes and hematopoietic stem and progenitor cells (HSPC). Compared with recombinant G-CSF, CoPP mobilizes higher number of HSPC and mature granulocytes. In contrast to G-CSF, CoPP does not increase the number of circulating T cells. Transplantation of CoPP-mobilized peripheral blood mononuclear cells (PBMC) results in higher chimerism and faster hematopoietic reconstitution than transplantation of PBMC mobilized by G-CSF. Although CoPP is used to activate Nrf2/HO-1 axis, the observed effects are Nrf2/HO- 1 independent. Concluding, CoPP increases expression of mobilization- related cytokines and has superior mobilizing efficiency compared with recombinant G-CSF. This observation could lead to the development of new strategies for the treatment of neutropenia and HSPC transplantation. |
URI: | http://hdl.handle.net/20.500.12128/12170 |
DOI: | 10.15252/emmm.201809571 |
ISSN: | 1757-4676 1757-4684 |
Pojawia się w kolekcji: | Artykuły (WNŚiT) |
Plik | Opis | Rozmiar | Format | |
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Szade_Cobalt_protoporphyrin_IX_increases_endogenous_G-CSF_and_mobilizes_HSC.pdf | 1,58 MB | Adobe PDF | Przejrzyj / Otwórz |
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