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Title: Antifungal styryloquinolines as Candida albicans efflux pump inhibitors : styryloquinolines are ABC transporter inhibitors
Authors: Cieślik, Wioleta
Szczepaniak, Joanna
Krasowska, Anna
Musioł, Robert
Keywords: styrylquinolines; Candida albicans; ABC transporters; Cdr1p
Issue Date: 2020
Citation: "Molecules (Basel)" iss. 2 (2020), art. no 345, s. 1-12
Abstract: Styrylquinolines are heterocyclic compounds that are known for their antifungal and antimicrobial activity. Metal complexation through hydroxyl groups has been claimed to be a plausible mechanism of action for these types of compounds. A series of novel structures with protected hydroxyl groups have been designed and synthesized to verify the literature data. Their antifungal activity against wild-type Candida albicans strain and mutants with silenced efflux pumps activity has been determined. Combinations with fluconazole revealed synergistic interactions that were dependent on the substitution pattern. These results open a new route for designing active antifungal agents on a styrylquinoline scaffold.
DOI: 10.3390/molecules25020345
ISSN: 1420-3049
Appears in Collections:Artykuły (WNŚiT)

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