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Title: Ileal transposition in rats influenced glucose metabolism and HSP70 levels
Authors: Stygar, Dominika
Sawczyn, Tomasz
Skrzep-Poloczek, Bronisława
Karcz-Socha, Iwona
Doleżych, Bogdan
Zawisza-Raszka, Agnieszka
Augustyniak, Maria
Żwirska-Korczala, Krystyna
Karcz, Wojciech Konrad
Keywords: HSP70; Ileal transposition; Metabolic surgery; Obesity surgery; Type 2 diabetes mellitus
Issue Date: 2015
Citation: Open Life Sciences, Vol. 10, iss. 1 (2015), s. 278-284
Abstract: Objective: Ileal transposition procedure (IT), in combination with sleeve gastrectomy, is widely used to induce diabetes remission and to control related metabolic abnormalities. A transposition of a long segment of distal ileum in obese Zucker rats improved glucose tolerance 6 months after IT. The premise of our study was to to examine the long - term effects of ileum transposition on the liver glycolytic enzymes content in a euglycemic group of operated Zucker rats. Methods: Twenty male Zucker rats underwent either the transposition of 50% distal ileum or a sham surgery. Six months after surgery, liver tissue concentrations of glycogen synthase kinase alpha (GSK-3α), glucose 6-phosphatase (G6PC), glycogen phosphorylase (PYGM) and phosphofructokinase (PFK) and HSP70 were assessed by immunoenzymatic methods. Results: HSP70 values were significantly higher in the IT group compared to SHAM. G6PC liver concentrations in the IT group were almost 1.45-fold lower than in the SHAM operated rats. Statistical analyses (F-test) showed HSP70 levels were significantly related to caveolin-1and SHAM group. Conclusions: Lowered glycolytic enzyme concentrations assessed in the liver suggest positive effects on glucose metabolism in long-term observations.
DOI: 10.1515/biol-2015-0029
ISSN: 2391-5412
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