http://hdl.handle.net/20.500.12128/3022
Tytuł: | Synthesis, structure and cytotoxic activity of mono- and dialkoxy derivatives of 5,8-quinolinedione |
Autor: | Kadela, Monika Jastrzębska, Maria Bębenek, Ewa Chrobak, Elwira Latocha, Małgorzata Kusz, Joachim Książek, Maria Boryczka, Stanisław |
Słowa kluczowe: | Alkoxy-5,8-quinolinedione; Crystal structure; Cytotoxic activity |
Data wydania: | 2016 |
Źródło: | Molecules, 2016, iss. 2, art. no 156 |
Abstrakt: | A series of 5,8-quinolinedione derivatives containing one or two alkoxy groups was synthesized and characterized by 1H- and 13C-NMR, IR and MS spectra. X-ray diffraction was used to investigate the crystal structures of 6-chloro-7-(2-cyjanoethoxy)-5,8-quinolinedione and 6,7-di(2,2,2-trifloroethoxy)-5,8-quinolinedione. All studied compounds were tested in vitro for their antiproliferative activity against three human cancer cell lines and human normal fibroblasts. Most of the compounds showed higher cytotoxicity than the starting compound, 6,7-dichloro-5,8-quinolinedione, and cisplatin, which was used as a reference agent. |
URI: | http://hdl.handle.net/20.500.12128/3022 |
DOI: | 10.3390/molecules21020156 |
ISSN: | 1420-3049 |
Pojawia się w kolekcji: | Artykuły (WNŚiT) |
Plik | Opis | Rozmiar | Format | |
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Kadela_Synthesis_structure_and_cytotoxic_activity.pdf | 2,33 MB | Adobe PDF | Przejrzyj / Otwórz |
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