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dc.contributor.authorWielkoszyński, Tomasz-
dc.contributor.authorZalejska-Fiolka, Jolanta-
dc.contributor.authorStrzelczyk, Joanna K.-
dc.contributor.authorOwczarek, Aleksander J.-
dc.contributor.authorCholewka, Armand-
dc.contributor.authorFurmański, Marcin-
dc.contributor.authorStanek, Agata-
dc.identifier.citationMediators of Inflammation, Art. ID 2784701, (2018), s. 1-19pl_PL
dc.description.abstractObjective. Oxidized cholesterol derivatives are thought to exert atherogenic effect thus adversely affecting vascular endothelium. The aim of the study was to assess the effect of 5α,6α-epoxycholesterol on experimentally induced hypercholesterolemia in rabbits, and the levels of homocysteine (HCY), asymmetric dimethylarginine (ADMA), paraoxonase-1 (PON-1), and inflammatory parameters (IL-6, TNF-α, CRP). Material and methods. The rabbits were divided into 3 groups, 8 animals each, and fed with basic fodder (C), basic fodder plus cholesterol (Ch) or basic fodder plus 5α,6α-epoxycholesterol, and unoxidized cholesterol (ECh). Serum concentrations of studied parameters were determined at 45-day intervals. The study was continued for six months. Results. We demonstrated that adding 5α,6α-epoxycholesterol to basic fodder significantly affected lipid status of the experimental animals, increasing total cholesterol and LDL cholesterol levels, as well as HCY and ADMA levels, whilst leaving the PON-1 activity unaffected. Additionally, the ECh group presented with significantly higher concentrations of inflammatory biomarkers (IL-6, TNF-α, and CRP). In the Ch group, lower yet significant (as compared to the C group) changes of levels of studied parameters were observed. Conclusion. Exposure of animals with experimentally induced hypercholesterolemia to 5α,6α-epoxycholesterol increases dyslipidaemia, endothelial dysfunction, and inflammatory response.pl_PL
dc.rightsUznanie autorstwa 3.0 Polska*
dc.subjectHypercholesterolemic Rabbitspl_PL
dc.titleOxysterols Increase Inflammation, Lipid Marker Levels and Reflect Accelerated Endothelial Dysfunction in Experimental Animalspl_PL
dc.identifier.doi10.1155/2018/ 2784701-
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