DC pole | Wartość | Język |
dc.contributor.author | Wielkoszyński, Tomasz | - |
dc.contributor.author | Zalejska-Fiolka, Jolanta | - |
dc.contributor.author | Strzelczyk, Joanna K. | - |
dc.contributor.author | Owczarek, Aleksander J. | - |
dc.contributor.author | Cholewka, Armand | - |
dc.contributor.author | Furmański, Marcin | - |
dc.contributor.author | Stanek, Agata | - |
dc.date.accessioned | 2018-04-26T06:17:12Z | - |
dc.date.available | 2018-04-26T06:17:12Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Mediators of Inflammation, Art. ID 2784701, (2018), s. 1-19 | pl_PL |
dc.identifier.issn | 0962-9351 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/3214 | - |
dc.description.abstract | Objective. Oxidized cholesterol derivatives are thought to exert atherogenic effect thus adversely affecting vascular endothelium. The aim of the study was to assess the effect of 5α,6α-epoxycholesterol on experimentally induced hypercholesterolemia in rabbits, and the levels of homocysteine (HCY), asymmetric dimethylarginine (ADMA), paraoxonase-1 (PON-1), and inflammatory parameters (IL-6, TNF-α, CRP). Material and methods. The rabbits were divided into 3 groups, 8 animals each, and fed with basic fodder (C), basic fodder plus cholesterol (Ch) or basic fodder plus 5α,6α-epoxycholesterol, and unoxidized cholesterol (ECh). Serum concentrations of studied parameters were determined at 45-day intervals. The study was continued
for six months. Results. We demonstrated that adding 5α,6α-epoxycholesterol to basic fodder significantly affected lipid status of the experimental animals, increasing total cholesterol and LDL cholesterol levels, as well as HCY and ADMA levels, whilst leaving the PON-1 activity unaffected. Additionally, the ECh group presented with significantly higher concentrations of inflammatory biomarkers (IL-6, TNF-α, and CRP). In the Ch group, lower yet significant (as compared to the C group) changes
of levels of studied parameters were observed. Conclusion. Exposure of animals with experimentally induced
hypercholesterolemia to 5α,6α-epoxycholesterol increases dyslipidaemia, endothelial dysfunction, and inflammatory response. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | Hypercholesterolemic Rabbits | pl_PL |
dc.subject | Plasma-Concentration | pl_PL |
dc.subject | Atherosclerosis | pl_PL |
dc.subject | Atorvastatin | pl_PL |
dc.subject | Proliferation | pl_PL |
dc.subject | Homocysteine | pl_PL |
dc.subject | Secretion | pl_PL |
dc.title | Oxysterols Increase Inflammation, Lipid Marker Levels and Reflect Accelerated Endothelial Dysfunction in Experimental Animals | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.1155/2018/ 2784701 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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