|Title:||Physical Stability and Viscoelastic Properties of Co-Amorphous Ezetimibe/Simvastatin System|
Correia, Natalia T.
|Keywords:||ezetimibe; simvastatin; co-amorphous; melt viscosity; solubility enhancement|
|Citation:||Pharmaceuticals, Vol. 12, iss. 1 (2019), Art. No. 40|
|Abstract:||The purpose of this paper is to examine the physical stability as well as viscoelastic properties of the binary amorphous ezetimibe–simvastatin system. According to our knowledge, this is the first time that such an amorphous composition is prepared and investigated. The tendency toward re-crystallization of the amorphous ezetimibe–simvastatin system, at both standard storage and elevated temperature conditions, have been studied by means of X-ray diffraction (XRD). Our investigations have revealed that simvastatin remarkably improves the physical stability of ezetimibe, despite the fact that it works as a plasticizer. Pure amorphous ezetimibe, when stored at room temperature, begins to re-crystallize after 14 days after amorphization. On the other hand, the ezetimibe-simvastatin binary mixture (at the same storage conditions) is physically stable for at least 1 year. However, the devitrification of the binary amorphous composition was observed at elevated temperature conditions (T = 373 K). Therefore, we used a third compound to hinder the re-crystallization. Finally, both the physical stability as well as viscoelastic properties of the ternary systems containing different concentrations of the latter component have been thoroughly investigated.|
|Appears in Collections:||Artykuły (WNŚiT)|
|Knapik-Kowalczuk_Physical_stability_and_viscoelastic_properties.pdf||1,89 MB||Adobe PDF||View/Open|
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